Obesity and the role of gut and adipose hormones in female reproduction (2025)

Article Navigation

Volume 12 Issue 5 September/October 2006
  • < Previous
  • Next >

Journal Article

Get access

,

Gabriella G. Gosman

4To whom correspondence should be addressed at: Department of Obstetrics, Gynecology and Reproductive Science, Division of Reproductive Endocrinology and Infertility, University of Pittsburgh School of Medicine, Magee-Womens Hospital, 300 Halket Street, Room 2314, Pittsburgh, PA 15213, USA. E-mail: ggosman@mail.magee.edu

Search for other works by this author on:

Oxford Academic

,

Heather I. Katcher

Search for other works by this author on:

Oxford Academic

Richard S. Legro

Search for other works by this author on:

Oxford Academic

Human Reproduction Update, Volume 12, Issue 5, September/October 2006, Pages 585–601, https://doi.org/10.1093/humupd/dml024

Published:

14 June 2006

Article history

Received:

15 March 2006

Accepted:

15 May 2006

Published:

14 June 2006

  • Views
    • Article contents
    • Figures & tables
    • Video
    • Audio
    • Supplementary Data
  • Cite

    Cite

    Gabriella G. Gosman, Heather I. Katcher, Richard S. Legro, Obesity and the role of gut and adipose hormones in female reproduction, Human Reproduction Update, Volume 12, Issue 5, September/October 2006, Pages 585–601, https://doi.org/10.1093/humupd/dml024

    Close

Search

Close

Search

Advanced Search

Search Menu

Abstract

Reproductive function declines at both extremes of human energy balance. The relationship between obesity and reproductive function is complex and incompletely understood. The literature has established the negative impact of excess energy stores on ovulatory function and investigated the mechanisms whereby this occurs. Furthermore, weight loss in obese anovulatory women increases ovulation and conception. Obesity and anti-obesity therapy effects on the endometrium, implantation and early fetal development have received less attention. The discovery of adipokines and enterokines greatly expands the ability to investigate the relationship between obesity, therapies to produce weight loss and reproductive function. In this review, we discuss select adipose and enteric signals. We focus on in vitro, animal and human data that lend biological plausibility to adipokines and enterokines as mediators of obesity and reproduction. Very little published work exists that directly addresses adipocyte and enteric signals in this specific role; therefore, much of this review is on the basis of a synthesis of the literature in three areas: (i) in vitro and in vivo evidence regarding the reproductive effects of these signals; (ii) adipokine and enterokine changes that occur with weight-loss therapies, focusing on hypocaloric diets, bariatric surgery and drugs that target adipocyte or enteric signals and (iii) reproductive changes produced by these weight-loss therapies.

bowel, energy balance, gut, obesity, reproduction

© The Author 2006. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Topic:

  • obesity
  • weight reduction
  • diet
  • hormones
  • adipocytes
  • leptin
  • reproductive physiological process
  • bariatric surgery
  • adipokines

Issue Section:

Reviews

You do not currently have access to this article.

Download all slides

Sign in

Get help with access

Personal account

  • Sign in with email/username & password
  • Get email alerts
  • Save searches
  • Purchase content
  • Activate your purchase/trial code
  • Add your ORCID iD

Sign in Register

Institutional access

    Sign in through your institution

    Sign in through your institution

  1. Sign in with a library card
  2. Sign in with username/password
  3. Recommend to your librarian

Institutional account management

Sign in as administrator

Get help with access

Institutional access

Access to content on Oxford Academic is often provided through institutional subscriptions and purchases. If you are a member of an institution with an active account, you may be able to access content in one of the following ways:

IP based access

Typically, access is provided across an institutional network to a range of IP addresses. This authentication occurs automatically, and it is not possible to sign out of an IP authenticated account.

Sign in through your institution

Choose this option to get remote access when outside your institution. Shibboleth/Open Athens technology is used to provide single sign-on between your institution’s website and Oxford Academic.

  1. Click Sign in through your institution.
  2. Select your institution from the list provided, which will take you to your institution's website to sign in.
  3. When on the institution site, please use the credentials provided by your institution. Do not use an Oxford Academic personal account.
  4. Following successful sign in, you will be returned to Oxford Academic.

If your institution is not listed or you cannot sign in to your institution’s website, please contact your librarian or administrator.

Sign in with a library card

Enter your library card number to sign in. If you cannot sign in, please contact your librarian.

Society Members

Society member access to a journal is achieved in one of the following ways:

Sign in through society site

Many societies offer single sign-on between the society website and Oxford Academic. If you see ‘Sign in through society site’ in the sign in pane within a journal:

  1. Click Sign in through society site.
  2. When on the society site, please use the credentials provided by that society. Do not use an Oxford Academic personal account.
  3. Following successful sign in, you will be returned to Oxford Academic.

If you do not have a society account or have forgotten your username or password, please contact your society.

Sign in using a personal account

Some societies use Oxford Academic personal accounts to provide access to their members. See below.

Personal account

A personal account can be used to get email alerts, save searches, purchase content, and activate subscriptions.

Some societies use Oxford Academic personal accounts to provide access to their members.

Viewing your signed in accounts

Click the account icon in the top right to:

  • View your signed in personal account and access account management features.
  • View the institutional accounts that are providing access.

Signed in but can't access content

Oxford Academic is home to a wide variety of products. The institutional subscription may not cover the content that you are trying to access. If you believe you should have access to that content, please contact your librarian.

Institutional account management

For librarians and administrators, your personal account also provides access to institutional account management. Here you will find options to view and activate subscriptions, manage institutional settings and access options, access usage statistics, and more.

Purchase

Subscription prices and ordering for this journal

Purchasing options for books and journals across Oxford Academic

Short-term Access

To purchase short-term access, please sign in to your personal account above.

Don't already have a personal account? Register

Obesity and the role of gut and adipose hormones in female reproduction - 24 Hours access

EUR €51.00

GBP £44.00

USD $55.00

Rental

Obesity and the role of gut and adipose hormones in female reproduction (3)

This article is also available for rental through DeepDyve.

Advertisement intended for healthcare professionals

Citations

Views

4,510

Altmetric

More metrics information

Metrics

Total Views 4,510

3,607 Pageviews

903 PDF Downloads

Since 1/1/2017

Month: Total Views:
January 2017 1
February 2017 9
March 2017 22
April 2017 37
May 2017 18
June 2017 20
July 2017 6
August 2017 96
September 2017 9
October 2017 8
November 2017 35
December 2017 113
January 2018 90
February 2018 54
March 2018 60
April 2018 119
May 2018 42
June 2018 30
July 2018 52
August 2018 221
September 2018 38
October 2018 27
November 2018 46
December 2018 27
January 2019 21
February 2019 93
March 2019 42
April 2019 85
May 2019 70
June 2019 38
July 2019 25
August 2019 32
September 2019 47
October 2019 67
November 2019 58
December 2019 44
January 2020 72
February 2020 66
March 2020 41
April 2020 67
May 2020 54
June 2020 47
July 2020 60
August 2020 77
September 2020 63
October 2020 67
November 2020 71
December 2020 58
January 2021 64
February 2021 53
March 2021 81
April 2021 65
May 2021 25
June 2021 22
July 2021 50
August 2021 50
September 2021 36
October 2021 39
November 2021 38
December 2021 33
January 2022 35
February 2022 31
March 2022 51
April 2022 52
May 2022 50
June 2022 25
July 2022 42
August 2022 39
September 2022 44
October 2022 49
November 2022 23
December 2022 48
January 2023 53
February 2023 34
March 2023 47
April 2023 48
May 2023 34
June 2023 28
July 2023 19
August 2023 39
September 2023 38
October 2023 49
November 2023 35
December 2023 46
January 2024 52
February 2024 77
March 2024 52
April 2024 40
May 2024 60
June 2024 47
July 2024 41
August 2024 40
September 2024 20
October 2024 15
November 2024 6

Citations

Powered by Dimensions

72 Web of Science

Altmetrics

×

Email alerts

Article activity alert

Advance article alerts

New issue alert

Receive exclusive offers and updates from Oxford Academic

Citing articles via

Google Scholar

  • Latest

  • Most Read

  • Most Cited

A systematic review and meta-analysis of double trophectoderm biopsy and/or cryopreservation in PGT: balancing the need for a diagnosis against the risk of harm
Functional hypothalamic amenorrhoea and polycystic ovarian morphology: a narrative review about an intriguing association
Infertility treatment and offspring blood pressure—a systematic review and meta-analysis
New insights into the ovulatory process in the human ovary
Evaluating the diagnostic accuracy of androgen measurement in polycystic ovary syndrome: a systematic review and diagnostic meta-analysis to inform evidence-based guidelines

More from Oxford Academic

Critical Care

Medicine and Health

Reproductive Medicine

Books

Journals

Advertisement intended for healthcare professionals

Obesity and the role of gut and adipose hormones in female reproduction (2025)
Top Articles
Latest Posts
Recommended Articles
Article information

Author: Kareem Mueller DO

Last Updated:

Views: 6059

Rating: 4.6 / 5 (46 voted)

Reviews: 93% of readers found this page helpful

Author information

Name: Kareem Mueller DO

Birthday: 1997-01-04

Address: Apt. 156 12935 Runolfsdottir Mission, Greenfort, MN 74384-6749

Phone: +16704982844747

Job: Corporate Administration Planner

Hobby: Mountain biking, Jewelry making, Stone skipping, Lacemaking, Knife making, Scrapbooking, Letterboxing

Introduction: My name is Kareem Mueller DO, I am a vivacious, super, thoughtful, excited, handsome, beautiful, combative person who loves writing and wants to share my knowledge and understanding with you.